Inhibition of tubulin-dependent ATPase activity in microtubule proteins from porcine brain by S100 protein.


Microtubule-associated proteins (MAPs) of brain microtubules exhibit an ATPase activity which is markedly enhanced by tubulin and Ca(2+). Addition of S100 protein decreased the tubulindependent Ca(2+)-ATPase activity by about 85%, but did not affect the activity without tubulin. The inhibition by S100 protein was concentration-dependent and the apparent K(m… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.