Inhibition of tubulin-dependent ATPase activity in microtubule proteins from porcine brain by S100 protein.

Abstract

Microtubule-associated proteins (MAPs) of brain microtubules exhibit an ATPase activity which is markedly enhanced by tubulin and Ca(2+). Addition of S100 protein decreased the tubulindependent Ca(2+)-ATPase activity by about 85%, but did not affect the activity without tubulin. The inhibition by S100 protein was concentration-dependent and the apparent K(m… (More)

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