Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro.

@article{Cannell2002InhibitionOT,
  title={Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro.},
  author={Graeme R. Cannell and Mark J Bailey and Ronald G Dickinson},
  journal={Life sciences},
  year={2002},
  volume={71 22},
  pages={
          2633-43
        }
}
Acyl glucuronides are reactive metabolites of carboxylate drugs, able to undergo a number of reactions in vitro and in vivo, including isomerization via intramolecular rearrangement and covalent adduct formation with proteins. The intrinsic reactivity of a particular acyl glucuronide depends upon the chemical makeup of the drug moiety. The least reactive acyl glucuronide yet reported is valproic acid acyl glucuronide (VPA-G), which is the major metabolite of the antiepileptic agent valproic… CONTINUE READING
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