Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences.

@article{Greenblatt1998InhibitionOT,
  title={Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences.},
  author={David J Greenblatt and Lisa L. von Moltke and Jerold S. Harmatz and Marian Counihan and Jennifer A. Graf and A. L. B. Durol and Polyxane Mertzanis and Su Xiang Duan and Charles E. Wright and Richard I. Shader},
  journal={Clinical pharmacology and therapeutics},
  year={1998},
  volume={64 3},
  pages={278-85}
}
BACKGROUND Macrolide antimicrobial agents may impair hepatic clearance of drugs metabolized by cytochrome P4503A isoforms. Potential interactions of triazolam, a substrate metabolized almost entirely by cytochrome P4503A in humans, with 3 commonly prescribed macrolides were identified using an in vitro metabolic model. The actual interactions, and their pharmacodynamic consequences, were verified in a controlled clinical study. METHODS In an in vitro model using human liver microsomes, 250… CONTINUE READING

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