Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.

@article{Lawson2007InhibitionOT,
  title={Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.},
  author={Brian R. Lawson and Yulia Manenkova and Jasimuddin Ahamed and Xiaoru Chen and Jian-Ping Zou and Roberto Baccala and Argyrios N. Theofilopoulos and Chong Yuan},
  journal={Journal of immunology},
  year={2007},
  volume={178 8},
  pages={5366-74}
}
Transmethylation affects several cellular events, including T cell activation, and blockade of this pathway may curtail inflammatory/autoimmune responses. Here, we demonstrate that transmethylation inhibition by a novel reversible S-adenosyl-l-homocysteine hydrolase inhibitor leads to immunosuppression by reducing phosphorylation of several key proteins involved in TCR signaling, including Akt, Erk1/2, and NF-kappaB. Remarkably, this effect was largely restricted to CD4 T cells and correlated… CONTINUE READING

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