Inhibition of translational initiation by Let-7 MicroRNA in human cells.

  title={Inhibition of translational initiation by Let-7 MicroRNA in human cells.},
  author={Ramesh S Pillai and Suvendra N Bhattacharyya and Caroline G Artus and Tabea Zoller and Nicolas Cougot and Eugenia I. Basyuk and Edouard Bertrand and W. Filipowicz},
  volume={309 5740},
MicroRNAs (miRNAs) are approximately 21-nucleotide-long RNA molecules regulating gene expression in multicellular eukaryotes. In metazoa, miRNAs act by imperfectly base-pairing with the 3' untranslated region of target messenger RNAs (mRNAs) and repressing protein accumulation by an unknown mechanism. We demonstrate that endogenous let-7 microribonucleoproteins (miRNPs) or the tethering of Argonaute (Ago) proteins to reporter mRNAs in human cells inhibit translation initiation. M(7)G-cap… CONTINUE READING
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Methods Enzymol

  • S F A Kolb
  • Methods Enzymol
  • 2005


  • S H Zhang, F A Kolb, L Jaskiewicz, E Westhof, W Filipowicz
  • Cell
  • 2004

Mol Cell

  • S S Boulon
  • Mol Cell
  • 2004


  • S R S Lerner
  • RNA
  • 2003

Embo J

  • S E Van Dijk
  • Embo J
  • 2002

Embo J

  • S C Verheggen
  • EMBO J
  • 2001

Proc Natl Acad Sci U S A

  • S E Billy, V Brondani, H Zhang, U Muller, W Filipowicz
  • Proc Natl Acad Sci U S A
  • 2001

Nucleic Acids Res

  • S E Basyuk, E Bertrand, L Journot
  • Nucleic Acids Res
  • 2000

Mol Cell Biol

  • S P Pelczar, W Filipowicz
  • Mol Cell Biol
  • 1998


  • S A M Femino, F S Fay, K Fogarty, R H Singer
  • Science
  • 1998

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