Inhibition of translation by the fungal toxin cyclopiazonic acid

Abstract

Cyclopiazonic acid is a toxic metabolite of fungal origin that inhibits protein synthesis in intact HeLa cells and eukaryotic cell-free systems. It has been shown that cyclopiazonic acid blocks the GTP- and EF-1-dependent binding of (3H)Phe-tRNA to 80S ribosomes. Moreover the translocation of N-Ac-(3H)Phe-tRNA by 80S ribosomes that takes place in the… (More)
DOI: 10.1007/BF01567197

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