Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis

@inproceedings{Cheng2016InhibitionOT,
  title={Inhibition of transforming growth factor β-activated kinase 1 prevents inflammation-related cartilage degradation in osteoarthritis},
  author={Jin Cheng and Xiaoqing Hu and Linghui Dai and Xin Zhang and Bo Ren and WeiLi Shi and Zhenlong Liu and Xiaoning Duan and Jiying Zhang and Xin Fu and Wenqing Chen and Yingfang Ao},
  booktitle={Scientific reports},
  year={2016}
}
Osteoarthritis (OA) is a common debilitating joint disorder, there's still no available disease-modifying drug for OA currently. This study aims to explore the role of TAK1 in OA pathogenesis and therapeutic efficiency of TAK1 inhibition for OA. The contribution of TAK1 to OA pathogenesis was investigated by intra-articular injection of TAK1-encoding adenovirus in rats. TAK1 inhibitor 5Z-7-induced expression changes of extracellular matrix (ECM)-related genes were detected by real-time PCR. The… CONTINUE READING

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