Inhibition of transepithelial sodium transport in the frog skin by a low molecular weight fraction of uremic serum.

@article{Bourgoignie1971InhibitionOT,
  title={Inhibition of transepithelial sodium transport in the frog skin by a low molecular weight fraction of uremic serum.},
  author={Jacques J. Bourgoignie and Saulo Klahr and Neal S. Bricker},
  journal={The Journal of clinical investigation},
  year={1971},
  volume={50 2},
  pages={303-11}
}
An inhibitor of transepithelial sodium transport was found in a low molecular weight fraction obtained from serum of patients with far advanced chronic renal disease. In 18 nondialyzed patients, the mean inhibition of short circuit current (SCC) was 24.9 +/-2.2% (SE). With a comparable fraction from 11 normal subjects. SCC decreased by only 5.3 +/-1.5… CONTINUE READING