Inhibition of transcription in vitro by binding of DNA (cytosine-5)-methylases to DNA templates containing cytosine analogs.

Abstract

DNA(cytosine-5)-methylases form tight complexes at their methylation sites when the target cytosine residue is substituted by analogs such as 5-azacytosine or 5-fluorocytosine. To test whether such complexes can block RNA transcription in vitro, template DNA-containing methylation sites were prepared, in which cytosine residues in either the (+)- or… (More)

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Cite this paper

@article{Som1994InhibitionOT, title={Inhibition of transcription in vitro by binding of DNA (cytosine-5)-methylases to DNA templates containing cytosine analogs.}, author={S. Som and Samuel R Friedman}, journal={The Journal of biological chemistry}, year={1994}, volume={269 42}, pages={25986-91} }