Inhibition of transcription elongation by the VHL tumor suppressor protein.

@article{Duan1995InhibitionOT,
  title={Inhibition of transcription elongation by the VHL tumor suppressor protein.},
  author={D Roxanne Duan and Arnim Pause and Wilson H. Burgess and Teijiro Aso and David Y-S Chen and Karla P. Garrett and Ronald C. Conaway and Joan W Conaway and W. Marston Linehan and Richard D. Klausner},
  journal={Science},
  year={1995},
  volume={269 5229},
  pages={1402-6}
}
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma. Here, a cellular transcription factor, Elongin (SIII), is identified as a functional target of the VHL protein. Elongin (SIII) is a… CONTINUE READING