Inhibition of trans-plasma membrane electron transport: a potential anti-leukemic strategy.

@article{Prata2010InhibitionOT,
  title={Inhibition of trans-plasma membrane electron transport: a potential anti-leukemic strategy.},
  author={Cecilia Prata and Carole H Grasso and Stefano Loizzo and Francesco Vieceli Dalla Sega and Cristiana Caliceti and Laura Zambonin and Diana Fiorentini and Gabriele Hakim and Michael V Berridge and Laura Landi},
  journal={Leukemia research},
  year={2010},
  volume={34 12},
  pages={1630-5}
}
The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity… CONTINUE READING