Inhibition of tongue reflex in rats by tooth pulp stimulation during cerebral ventricle perfusion with (6–11) substance P analogs

@article{Zubrzycka1997InhibitionOT,
  title={Inhibition of tongue reflex in rats by tooth pulp stimulation during cerebral ventricle perfusion with (6–11) substance P analogs},
  author={Maria Zubrzycka and Anna Janecka and Wiktor Koziolkiewicz and Wladyslaw Z Traczyk},
  journal={Brain Research},
  year={1997},
  volume={753},
  pages={128-132}
}
The effect of 12 C-terminal hexapeptide analogs of substance P perfused into the cerebral ventricles on the trigemino-hypoglossal reflex caused by incisor pulp stimulation in rats was investigated. A substitution of the L-isomer by D at position 6, 7, or 8 of the substance P analogs used in this study caused the most pronounced inhibition of the trigemino-hypoglossal reflex. A correlation between the degree of inhibition of the reflex and concentration of the peptide used was observed. 

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