Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty.

@article{Roqu2000InhibitionOT,
  title={Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty.},
  author={Merc{\'e} Roqu{\'e} and Ernane D Reis and Valentin Fuster and Adrian M Padurean and John T. Fallon and Mark B. Taubman and James H. Chesebro and Juan Jose Badimon},
  journal={Journal of the American College of Cardiology},
  year={2000},
  volume={36 7},
  pages={2303-10}
}
OBJECTIVES We investigated the in vivo effects of tissue factor (TF) inhibition with recombinant tissue factor pathway inhibitor (rTFPI) on acute thrombus formation and intimal hyperplasia and the in vitro effects on smooth muscle cell migration and proliferation. BACKGROUND Inhibition of TF with TFPI has been shown to reduce intimal hyperplasia in experimental models. However, its effects after coronary angioplasty and the cellular mechanisms involved have not been investigated. METHODS… CONTINUE READING

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