Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma.

@article{Oliveira2012InhibitionOT,
  title={Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma.},
  author={Andreia da Silva de Oliveira and Luize Gonçalves Lima and Andr{\'e}a Mariano-Oliveira and Daniel Escorsim Machado and Luiz E. Nasciutti and John F. Andersen and Lars Christian Petersen and Ivo M B Francischetti and Robson de Queiroz Monteiro},
  journal={Thrombosis research},
  year={2012},
  volume={130 3},
  pages={e163-70}
}
Melanoma is a highly metastatic cancer and there is strong evidence that the clotting initiator protein, tissue factor (TF), contributes to its aggressive pattern. TF inhibitors may attenuate primary tumor growth and metastasis. In this study, we evaluated the effect of ixolaris, a TF inhibitor, on a murine model of melanoma B16F10 cells. Enzymatic assays… CONTINUE READING