Inhibition of tissue angiotensin-converting enzyme with quinapril reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling.

@article{Nong1996InhibitionOT,
  title={Inhibition of tissue angiotensin-converting enzyme with quinapril reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling.},
  author={Zengxuang Nong and J M Stassen and Lieve Moons and D{\'e}sir{\'e} Collen and Stefan Janssens},
  journal={Circulation},
  year={1996},
  volume={94 8},
  pages={1941-7}
}
BACKGROUND Angiotensin II may contribute to hypoxic pulmonary hypertension via its vasoconstrictor and growth-stimulatory effects on vascular smooth muscle cells (VSMCs). Therefore, the use of ACE inhibitors might reduce hypoxic pulmonary hypertension by decreasing pulmonary vasomotor tone or vascular remodeling. METHODS AND RESULTS Pulmonary hemodynamics… CONTINUE READING