Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

@article{Meinkoth1992InhibitionOT,
  title={Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.},
  author={Judy L. Meinkoth and Paul K. Goldsmith and Allen M. Spiegel and James R. Feramisco and Gerard N. Burrow},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 19},
  pages={
          13239-45
        }
}
Thyrotropin (TSH) is an important regulator of thyroid follicular cells. While its role in the maintenance of differentiated functions is undisputed, its role as a mitogen is less clear. TSH induces DNA synthesis and cell proliferation in some cells, while in others, TSH is mitogenic only in the presence of additional growth factors such as insulin-like growth factor-1. TSH causes elevations in intracellular cAMP and is thought to utilize this second messenger system in its mitogenic action. We… CONTINUE READING

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