Inhibition of thrombocytopenic petechiae by exogenous serotonin administration.

@article{Sweetman1981InhibitionOT,
  title={Inhibition of thrombocytopenic petechiae by exogenous serotonin administration.},
  author={H E Sweetman and David Shepro and Herbert B. Hechtman},
  journal={Haemostasis},
  year={1981},
  volume={10 2},
  pages={65-78}
}
The effect of serotonin on vascular fragility, visible as petechiae, was examined in antiplatelet serum-induced thrombocytopenic hamsters. Serotonin was administered intravenously or intraperitoneally, and following a single injection of 0.5 mg/100 g body weight, a temporary inhibition of petechial formation for approximately 1 h was observed. Repeated serotonin injections maintained animals free of petechiae for the 4-hour period of administration. Plasma levels of serotonin and the effect of… CONTINUE READING