Inhibition of thrombin by sulfated polysaccharides isolated from green algae.

  title={Inhibition of thrombin by sulfated polysaccharides isolated from green algae.},
  author={Yumiko Hayakawa and Takaaki Hayashi and Jin Bae Lee and P Srisomporn and Mizuo Maeda and Toshio Ozawa and Nobuo Sakuragawa},
  journal={Biochimica et biophysica acta},
  volume={1543 1},
Eight different sulfated polysaccharides were isolated from Chlorophyta. All exhibited thrombin inhibition through a heparin cofactor II (HCII)-dependent pathway, and their effects on the inhibition of thrombin were more potent than those of heparin or dermatan sulfate. In particular, remarkably potent thrombin inhibition was found for the sulfated polysaccharides isolated from the Codiales. In the presence of these sulfated polysaccharides, both the recombinant HCII (rHCII) variants Lys(173… CONTINUE READING

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