Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins.

@article{Schoonderwoert2000InhibitionOT,
  title={Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins.},
  author={Vincent Th G Schoonderwoert and Joost C M Holthuis and Satoshi Tanaka and Sharon A Tooze and Gerard J. M. Martens},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 17},
  pages={5646-54}
}
Vacuolar H+-ATPases (V-ATPases) are multisubunit enzymes that acidify various intracellular organelles, including secretory pathway compartments. We have examined the effects of the specific V-ATPase inhibitor bafilomycin A1 (Baf) on the intracellular transport, sorting, processing and release of a number of neuroendocrine secretory proteins in primary Xenopus intermediate pituitary cells. Ultrastructural examination of Baf-treated intermediate pituitary cells revealed a reduction in the amount… CONTINUE READING

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