Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm.

Abstract

BACKGROUND Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has shown that calpain, caspase-3, and the ubiquitin-proteasome… (More)
DOI: 10.1097/ALN.0000000000000245

Topics

Statistics

0204060201520162017
Citations per Year

Citation Velocity: 11

Averaging 11 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Smuder2014InhibitionOT, title={Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm.}, author={Ashley J. Smuder and W. Bradley Nelson and Matthew B. Hudson and Andreas N. Kavazis and Scott Powers}, journal={Anesthesiology}, year={2014}, volume={121 1}, pages={115-26} }