Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells.

Abstract

Efflux-pumps mediated by P-glycoprotein increase the level of resistance to antibiotics in bacteria and to cytostatics in tumor cells due to decreased drug accumulation, and are also involved in the operation of blood brain barrier. Different compounds are able to enhance drug retention in the cells by inhibiting the efflux-pump mechanism of multidrug… (More)

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Cite this paper

@article{Molnr1997InhibitionOT, title={Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells.}, author={Judit M{\'a}ria Moln{\'a}r and Aviv Hever and I Fakla and J. Fischer and I Ocsovski and Andor Aszalos}, journal={Anticancer research}, year={1997}, volume={17 1A}, pages={481-6} }