Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis

@article{Siuciak2006InhibitionOT,
  title={Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis},
  author={J. Siuciak and D. Chapin and J. Harms and L. Lebel and S. McCarthy and L. Chambers and A. Shrikhande and S. Wong and F. Menniti and C. J. Schmidt},
  journal={Neuropharmacology},
  year={2006},
  volume={51},
  pages={386-396}
}
Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. We report that papaverine is a potent, specific inhibitor of PDE10A and use this compound to explore the role of PDE10A in regulating striatal function. Papaverine administration produces an increase in striatal tissue levels of cGMP and an increase in extracellular cAMP measured by microdialysis. These cyclic nucleotide… Expand
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