• Corpus ID: 34315034

Inhibition of the stimulatory effect of ACTH on adrenal and ovarian blood flow by indomethacin in the dog.

@article{Varga1979InhibitionOT,
  title={Inhibition of the stimulatory effect of ACTH on adrenal and ovarian blood flow by indomethacin in the dog.},
  author={Bertalan Varga and E Stark and G. Folly},
  journal={Acta physiologica Academiae Scientiarum Hungaricae},
  year={1979},
  volume={54 2},
  pages={
          123-8
        }
}
In anoestrous dogs heated thermocouples were inserted into one of the adrenals and ovaries. The basal adrenal and ovarian blood flow was recorded and enhanced by 1.2, 2.5 or 5.0 micrograms/kg of intravenous ACTH before and after the intravenous administration of 20 or 50 mg/kg of indomethacin. Indomethacin, depending on the dose and on the time elapsing after its administration inhibited the enhancing effect of ACTH on adrenal and ovarian blood flow. Since indomethacin is a specific inhibitor… 
Effects of stimulation on steroid output and perfusion medium flow rate in the isolated perfused rat adrenal gland in situ.
TLDR
The data suggest that ACTH and dbcAMP evoke specific responses in the adrenal vasculature, resulting in relatively decreased intraglandular vascular resistance, and suggest that the secretory functions of the inner adrenocortical zones are subject to the additional control of vascular elements in the intact gland.