Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice.

@article{Li2017InhibitionOT,
  title={Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice.},
  author={Na Li and Zhang-Sen Zhou and Yang Shen and Jie Xu and Hong-Hua Miao and Ying Xiong and Feng Xu and Boliang Li and Jie Luo and Bao-Liang Song},
  journal={Hepatology},
  year={2017},
  volume={65 6},
  pages={1936-1947}
}
Obesity is a critical risk factor for hepatocellular carcinoma (HCC). However, it remains unknown whether inhibition of de novo lipid biosynthesis can suppress HCC. In this study, we blocked the sterol regulatory element-binding protein (SREBP) pathway, one of the key determinants of lipid homeostasis, by ablating 78-kDa cell-surface glycoprotein or SREBP… CONTINUE READING