Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra.

@article{MACGILLIVRAY2011InhibitionOT,
  title={Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra.},
  author={LINDSEY E. S. MACGILLIVRAY and Katelyn B Reynolds and M Sickand and Patricia I Rosebush and Michael F. Mazurek},
  journal={Synapse},
  year={2011},
  volume={65 11},
  pages={1166-72}
}
Drugs that selectively inhibit the serotonin transporter (SERT) are widely used in the treatment of depression and anxiety disorders. These agents are associated with a range of extrapyramidal syndromes such as akathisia, dystonia, dyskinesia and parkinsonism, suggesting an effect on dopaminergic transmission. We studied the time course of changes in dopaminergic neurons in the substantia nigra (SN) after initiation of two different SERT inhibitors, citalopram and fluoxetine. In the first… CONTINUE READING

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