Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.

@article{Pereira2010InhibitionOT,
  title={Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy.},
  author={Mar{\'i}lia Gabriella Alves Goulart Pereira and Christiane Becari and Jos{\'e} Ant{\'o}nio Oliveira and Maria Cristina Oliveira Salgado and Norberto Garcia-Cairasco and Claudio M Costa-Neto},
  journal={Clinical science},
  year={2010},
  volume={119 11},
  pages={
          477-82
        }
}
The RAS (renin-angiotensin system) is classically involved in BP (blood pressure) regulation and water-electrolyte balance, and in the central nervous system it has been mostly associated with homoeostatic processes, such as thirst, hormone secretion and thermoregulation. Epilepsies are chronic neurological disorders characterized by recurrent epileptic seizures that affect 1-3% of the world's population, and the most commonly used anticonvulsants are described to be effective in approx. 70% of… CONTINUE READING

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