Inhibition of the release of slow‐reacting substance of anaphylaxis by inhibitors of lipoxygenase activity

  title={Inhibition of the release of slow‐reacting substance of anaphylaxis by inhibitors of lipoxygenase activity},
  author={J. R. WALKER and J. Boot and B. Cox and W. Dawson},
  journal={Journal of Pharmacy and Pharmacology},
  • J. R. WALKER, J. Boot, +1 author W. Dawson
  • Published 1 September 1980
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
Recent evidence has suggested that both 5-hydroxy-6glutathionyl-eicosatetraenoic acid (leukotriene C) and its probable degradation product 5-hydroxy-6-cysteinylglycine eicosatetraenoic acid (leukotriene D) contribute to the biological activity hitherto referred to as slowreacting substance of anaphylaxis (SRS-A) (Orning et al 1980; Morris et a1 1980b). These compounds are believed to derive from 5-hydroperoxy-eicosatetraenoic acid (5-HPETE) produced from the oxygenation of arachidonic acid by a… Expand

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