Inhibition of the pro‐oxidant effects of benoxaprofen on poiymorpbonuclear leucocytes by retinol acetate in vitro

  title={Inhibition of the pro‐oxidant effects of benoxaprofen on poiymorpbonuclear leucocytes by retinol acetate in vitro},
  author={R. Anderson},
  journal={British Journal of Dermatology},
  • R. Anderson
  • Published 1982
  • Medicine
  • British Journal of Dermatology
SIR: Sun sensitivity and onycholysis are side-effects of the recently introduced non-steroidal anti-inflammatory drug benoxaprofen (Ridolfo, Nickander & Mikulaschek, 1979)We have recently suggested that these adverse reactions may be related to the ability of the drug to stimulate oxidative metabolism and release of lysozomal enzymes in human leucocytes (Anderson et al, 1982), These pro-oxidant effects are evident both in vitro and in vivo. It therefore seemed possible that anti-oxidants could… Expand
2 Citations
Benoxaprofen activation of suppressor activity in mononuclear leucocytes by a pro-oxidative mechanismin vitro
Findings show that benoxaprofen induces suppressor activity in MNL by a pro-oxidative mechanism dependent upon intact cellular oxidative metabolism, which may be an important anti-inflammatory mechanism. Expand
Potentiation of the generation of reactive oxidants by human phagocytes during exposure to benoxaprofen and ultraviolet radiation in vitro
It is postulated that the pro‐oxidative interactions which occur between human phagocytes, benoxaprofen and ultraviolet radiation cause the dermatological side‐effects of benoxAProfen. Expand


Increased leucoattractant binding and reversible inhibition of neutrophil motility mediated by the peroxidase/H2O2/halide system: effects of ascorbate, cysteine, dithiothreitol, levamisole and thiamine.
Human blood neutrophils manifested markedly decreased motility following exposure to the horseradish peroxidase (HRP)/H2O2/halide system in vitro and completely recovered normal or increased motility induced by the leucoattractants endotoxin-activated serum or synthetic chemotactic tripeptide f-met-leu-phe. Expand
Inhibition of polymorphonuclear leucocyte motility by benoxaprofen related to a leucoattractant receptor blocking mechanism and activation of oxidative metabolism Submitted for publication
  • 1982
Fenoprofen and benoxaprofen
  • Clinics in Rheumatic
  • 1979