Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

@article{Bertram2006InhibitionOT,
  title={Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.},
  author={Jerod Bertram and James W. Peacock and Clara Wee Keat Tan and Alice L-F Mui and Stephen W. Chung and Martin E. Gleave and Shoukat Dedhar and Michael E. Cox and Christopher J Ong},
  journal={Cancer research},
  year={2006},
  volume={66 9},
  pages={4781-8}
}
Rationally designed therapeutics that target the phosphatidylinositol 3'-kinase (PI3K) cell survival pathway are currently in preclinical and clinical development for cancer therapy. Drugs targeting the PI3K pathway aim to inhibit proliferation, promote apoptosis, and enhance chemosensitivity and radiosensitivity of cancer cells. The phosphatase and tensin homologue (PTEN) phosphatidylinositol 3'-phosphatase is a key negative regulator of the PI3K pathway. Inactivation of the PTEN tumor… CONTINUE READING

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