Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

@article{Wilson1986InhibitionOT,
  title={Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.},
  author={Emily Wilson and Michael C. Olcott and Robert M. Bell and Alfred H. Merrill and John David Lambeth},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 27},
  pages={
          12616-23
        }
}
The neutrophil oxidative burst is characterized by increased cellular O2 consumption due to the activation of a membrane-associated superoxide-generating NADPH-oxidase. The response is triggered by a variety of stimuli, including opsonized zymosan, formylmethionylleucinephenylalanine (FMLP), arachidonate, short-chain diacylglycerols, and phorbol myristate acetate (PMA). We herein demonstrate that incubation of cells with sphinganine or sphingosine blocks or reverses activation by these agonists… Expand
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
TLDR
Sphingosine is used to investigate the pathways for agonist-induced secretion of neutrophil granule contents and concludes that at least two mechanisms participate in the regulation of specific and azurophilic granule secretion, respectively: a protein kinase C-dependent pathway and a calcium- dependent pathway which does not involve protein kinases C. Expand
Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.
TLDR
TMS appears to be a superior pharmacological agent, compared to SPN derivatives or other PKC inhibitors, for suppression of neutrophil overfunction associated with inflammatory processes and tissue injury. Expand
The neutrophil respiratory burst. Responses to fatty acids, N-formylmethionylleucylphenylalanine and phorbol ester suggest divergent signalling mechanisms.
TLDR
The results show that, unlike fMLF and TPA, the fatty acids do not cause hydrolysis of PtdCho by phospholipase D, however, the data indirectly suggests that the fatty fatty acids may initiate the phospholIPase-D-catalysed hydrolyzing ofospholipids other than Ptd Cho. Expand
Complete and Reversible Inhibition of NADPH Oxidase in Human Neutrophils by Phenylarsine Oxide at a Step Distal to Membrane Translocation of the Enzyme Subunits (*)
TLDR
PAO is the first complete and reversible inhibitor of NADPH oxidase which could provide the basis for new therapeutical approaches in inflammatory diseases. Expand
Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.
TLDR
Results suggest that a third signaling pathway, distinct from changes in [Ca2+]i and activation of protein kinase C, is involved in the response of neutrophils to chemoattractants. Expand
Effects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies
TLDR
The complete inhibition by SPN of ESR signal and CL of stimulated PMN confirms that this compound or one of its metabolites act at the level of NADPH-oxidase, the key enzyme responsible for production of oxygen-derived free radicals. Expand
Charge-dependent regulation of NADPH oxidase activities in intact and subcellular systems of polymorphonuclear leukocytes.
TLDR
A charge-dependent process, which does not use protein kinase C, may play an important role in the reaction leading to NADPH oxidase activation, and this may be related to the interaction of plasma membranes with the cytosolic activation factor. Expand
Charge-dependent regulation of NADPH oxidase activity in guinea-pig polymorphonuclear leukocytes.
TLDR
The results suggest that triggering of NADPH oxidase activation involves a reaction(s) that is regulated by membrane charges, and this was insensitive to H-7 and W-7. Expand
The Fatty Acid Bimodal Action on Superoxide Anion Production by Human Adherent Monocytes under Phorbol 12-Myristate 13-Acetate or Diacylglycerol Activation Can Be Explained by the Modulation of Protein Kinase C and p47phox Translocation (*)
TLDR
The results emphasize the fact that in intact cells the capacity of both FAs to potentiate or depress the HAM O production is mediated by a direct action on the PKC membranes translocation leading to a simultaneous endogenous phosphorylation and membrane translocation of p47phox. Expand
Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
TLDR
The data suggest that ceramides, generated through activation of the sphingomyelin cycle, act as negative regulators of FcγR-mediated phagocytosis, and phospholipase D is an intracellular target of ceramide action. Expand
...
1
2
3
4
5
...

References

SHOWING 1-4 OF 4 REFERENCES
On the role of superoxide anion radicals in skin tumour promotion.
TLDR
It is concluded that superoxide anion radicals--if related to promotion at all--may play a role in stage II rather than in stage I of mouse skin tumour promotion. Expand
Cont . TOP . Zmmunobiol . 235 - 236 1355 - 1368 Znuest
  • 1985
Bwchem
  • Biophys . Res . Commun
  • 1981
Bwchem
  • Biophys . Res . Commun
  • 1978