Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.

@article{Jodoin2002InhibitionOT,
  title={Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols.},
  author={Julie Jodoin and Michel Demeule and Richard B{\'e}liveau},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1542 1-3},
  pages={149-59}
}
Many beneficial proprieties have been associated with polyphenols from green tea, such as chemopreventive, anticarcinogenic, antiatherogenic and antioxidant actions. In this study, we investigated the effects of green tea polyphenols (GTPs) and their principal catechins on the function of P-glycoprotein (P-gp), which is involved in the multidrug resistance phenotype of cancer cells. GTPs (30 microg/ml) inhibit the photolabeling of P-gp by 75% and increase the accumulation of rhodamine-123 (R… CONTINUE READING

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