Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid

@article{Brusque2002InhibitionOT,
  title={Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid},
  author={Ana Maria Brusque and Rafael Borba Rosa and Patricia F Schuck and Karina Borges Dalcin and Moacir Wajner},
  journal={Neurochemistry International},
  year={2002},
  volume={40},
  pages={593-601}
}
Propionic and methylmalonic acidemic patients have severe neurologic symptoms whose etiopathogeny is still obscure. Since increase of lactic acid is detected in the urine of these patients, especially during metabolic decompensation when high concentrations of methylmalonate (MMA) and propionate (PA) are produced, it is possible that cellular respiration may be impaired in these individuals. Therefore, we investigated the effects of MMA and PA (1, 2.5 and 5mM), the principal metabolites which… CONTINUE READING
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