Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation

@inproceedings{Yamamori2015InhibitionOT,
  title={Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation},
  author={Tohru Yamamori and Satoshi Ike and Tomoki Bo and Tomoya Sasagawa and Yuri Sakai and Motofumi Suzuki and Kumiko Yamamoto and Masaki Nagane and Hironobu Yasui and Osamu Inanami and Donald D. Newmeyer},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Accumulating evidence suggests that mitochondrial dynamics is crucial for the maintenance of cellular quality control and function in response to various stresses. However, the role of mitochondrial dynamics in cellular responses to ionizing radiation (IR) is still largely unknown. In this study, we provide evidence that IR triggers mitochondrial fission mediated by the mitochondrial fission protein dynamin-related protein 1 (Drp1). We also show IR-induced mitotic catastrophe (MC), which is a… CONTINUE READING
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