Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death

@article{Borrajo2014InhibitionOT,
  title={Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death},
  author={Antonio Carbajales Borrajo and Ana Isabel Rodr{\'i}guez-P{\'e}rez and Bego{\~n}a Villar-Cheda and Marı́a Jos{\'e} Guerra and Jose L Labandeira-Garcia},
  journal={Neuropharmacology},
  year={2014},
  volume={85},
  pages={1-8}
}
Several recent studies have shown that activation of the RhoA/Rho-associated kinase (ROCK) pathway is involved in the MPTP-induced dopaminergic cell degeneration and possibly in Parkinson's disease. ROCK inhibitors have been suggested as candidate neuroprotective drugs for Parkinson's disease. However, the mechanism responsible for the increased survival of dopaminergic neurons after treatment with ROCK inhibitors is not clear. We exposed primary (neuron-glia) mesencephalic cultures, cultures… CONTINUE READING
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