Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.

@article{Sunnen2011InhibitionOT,
  title={Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.},
  author={C Nicole Sunnen and Amy L. Brewster and Joaquin N Lugo and Fabiola Vanegas and Eric Turcios and Shivani Mukhi and Deena Parghi and G V D'arcangelo and Anne E. Anderson},
  journal={Epilepsia},
  year={2011},
  volume={52 11},
  pages={2065-75}
}
PURPOSE Increased activity of mTOR Complex 1 (mTORC1) has been demonstrated in cortical dysplasia and tuberous sclerosis complex, as well as in animal models of epilepsy. Recent studies in such models revealed that inhibiting mTORC1 with rapamycin effectively suppressed seizure activity. However, seizures can recur after treatment cessation, and continuous rapamycin exposure can adversely affect animal growth and health. Here, we evaluated the efficacy of an intermittent rapamycin treatment… CONTINUE READING

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