Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

@inproceedings{Tan2013InhibitionOT,
  title={Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling},
  author={Ying Xim Tan and Boryana N. Manz and Tanya S. Freedman and Chao Zhang and Kevan M. Shokat and Arthur Weiss},
  year={2013}
}
VOLUME 15 NUMBER 2 FEBRUARY 2014 nature immunology Signals transduced by the T cell antigen receptor (TCR) are critical for the selection and maturation of thymocytes and the homeostasis and activation of peripheral T cells, as well as the specification of effector and memory cell fates. Hence, the initiation of TCR signaling in response to antigens of diverse affinities at different stages of T cell development must be tightly regulated. Such regulation ensures the selection of a protective T… CONTINUE READING

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