Inhibition of the intracellular transport of influenza viral RNA by actinomycin D

@article{Vogel1995InhibitionOT,
  title={Inhibition of the intracellular transport of influenza viral RNA by actinomycin D},
  author={Ulla Vogel and Ch. Scholtissek},
  journal={Archives of Virology},
  year={1995},
  volume={140},
  pages={1715-1723}
}
In primary chicken embryo cells infected with fowl plague virus addition of actinomycin D at defined times during the infection cycle has different consequences on viral replication. If actinomycin D is added immediately after infection with a concentration, which inhibits viral RNA synthesis only partially, it interferes with the nucleo-cytoplasmic transport of all viral RNA species (mRNA and vRNA) so far tested. If actinomycin D is present during infection (adsorption, penetration and… CONTINUE READING
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