Inhibition of the intestinal sodium-coupled glucose transporter 1 (SGLT1) by extracts and polyphenols from apple reduces postprandial blood glucose levels in mice and humans.

@article{Schulze2014InhibitionOT,
  title={Inhibition of the intestinal sodium-coupled glucose transporter 1 (SGLT1) by extracts and polyphenols from apple reduces postprandial blood glucose levels in mice and humans.},
  author={Christine Schulze and Adina Bangert and Gabor Kottra and Kerstin Elisabeth Geillinger and Bettina Schwanck and Henning Vollert and Wolfgang Blaschek and Hannelore Daniel},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 9},
  pages={1795-808}
}
SCOPE There is a growing interest in food constituents that could reduce intestinal glucose absorption to prevent overshooting plasma glucose and insulin levels in patients with prediabetes and diabetes mellitus type 2. METHODS AND RESULTS We here demonstrate that an extract and individual polyphenols from apple diminish sodium-coupled glucose transporter 1 (SGLT1) mediated glucose uptake in vitro and in vivo. Inhibition of transport of sugars by SGLT1 was shown in Xenopus oocytes and in mice… CONTINUE READING