Inhibition of the interleukin-6 signaling pathway: a strategy to induce immune tolerance.

@article{Zhang2014InhibitionOT,
  title={Inhibition of the interleukin-6 signaling pathway: a strategy to induce immune tolerance.},
  author={Cheng Zhang and Xiaoying Zhang and Xing-hua Chen},
  journal={Clinical reviews in allergy & immunology},
  year={2014},
  volume={47 2},
  pages={163-73}
}
Interleukin-6 (IL-6) is a proinflammatory cytokine that is multifunctional, with multifaceted effects. IL-6 signaling plays a vital role in the control of the differentiation and activation of T lymphocytes by inducing different pathways. In particular, IL-6 controls the balance between Th17 cells and regulatory T (Treg) cells. An imbalance between Treg and Th17 cells is thought to play a pathological role in various immune-mediated diseases. Deregulated IL-6 production and signaling are… CONTINUE READING
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