Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury.

@article{Chou2017InhibitionOT,
  title={Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury.},
  author={Austin C. Chou and Karen Krukowski and Timothy D. Jopson and Ping Jun Zhu and Mauro Costa-Mattioli and Peter Walter and Susanna Rosi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 31},
  pages={
          E6420-E6426
        }
}
Traumatic brain injury (TBI) is a leading cause of long-term neurological disability, yet the mechanisms underlying the chronic cognitive deficits associated with TBI remain unknown. Consequently, there are no effective treatments for patients suffering from the long-lasting symptoms of TBI. Here, we show that TBI persistently activates the integrated stress response (ISR), a universal intracellular signaling pathway that responds to a variety of cellular conditions and regulates protein… CONTINUE READING
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Management of traumatic brain injury patients

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