Inhibition of the hyperpolarization-activated current (i f) of rabbit SA node myocytes by niflumic acid

Abstract

The effects of the amphiphilic substance niflumic acid (NFA) were examined in myocytes isolated from the sino-atrial node of the rabbit heart. NFA (50 and 500 μM), for 30–60 s, produced a reversible negative chronotropic effect by reducing the rate of diastolic depolarization, suggesting an inhibitory effect on the hyperpolarization-activated “pacemaker… (More)
DOI: 10.1007/BF02253840

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