Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.

@article{Mazumder1996InhibitionOT,
  title={Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.},
  author={Amitabha Mazumder and Nouri Neamati and Joshua O. Ojwang and Sham Sunder and Robert F. Rando and Yves Pommier},
  journal={Biochemistry},
  year={1996},
  volume={35 43},
  pages={
          13762-71
        }
}
An oligonucleotide (T30177) composed entirely of deoxyguanosine and thymidine has previously been shown to fold upon itself in the presence of potassium into a highly stable four-stranded DNA structure containing two stacked deoxyguanosine quartets (G4s). T30177 also protects host cells from the cytopathic effects of human immunodeficiency virus type 1 (HIV-1). We report that this G4 oligonucleotide is the most potent inhibitor of HIV-1 integrase identified to date, with IC50 values in the… CONTINUE READING
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