Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.

  title={Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.},
  author={Benjamin Suenkel and Frank Fischer and Clemens Steegborn},
  journal={Bioorganic & medicinal chemistry letters},
  volume={23 1},
Sirtuins are NAD(+) consuming protein deacylases involved in many cellular processes from DNA-repair to metabolism. Their contribution to age-related and metabolic diseases makes them attractive pharmaceutical targets. Few pharmacological inhibitors have been reported yet for human Sirt5 since substrates and assays for reliable testing of its activity were unavailable until recently, and most modulators of other Sirtuins were not tested against Sirt5 and therefore have only partially… CONTINUE READING
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