Inhibition of the histamine-induced Ca2+ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics.

@article{Tas2008InhibitionOT,
  title={Inhibition of the histamine-induced Ca2+ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics.},
  author={Piet W. L. Tas and Christina Stoessel and Norbert Roewer},
  journal={European journal of anaesthesiology},
  year={2008},
  volume={25 12},
  pages={976-85}
}
BACKGROUND AND OBJECTIVE Vasoactive substances such as histamine, acetylcholine or ATP increase the [Ca2+]i of endothelial cells, which leads to the activation of nitric oxide synthase (eNOS). The NO produced by this enzyme relaxes the underlying smooth muscle. Evidence suggests that eNOS activation is dependent on agonist-induced Ca2+ entry. Recently we have shown that in human endothelial cells (HUVEC), this Ca2+ entry is sensitive to isoflurane. The objective here was to study the mechanism… CONTINUE READING