Corpus ID: 1825620

Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis-(thiosemicarbazone).

@article{Sartorelli1967InhibitionOT,
  title={Inhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis-(thiosemicarbazone).},
  author={Alan C. Sartorelli and Barbara A. Booth},
  journal={Cancer research},
  year={1967},
  volume={27 9},
  pages={
          1614-9
        }
}
The tumor-inhibitory potency of combinations of the cupric chelate of kethoxal bis(thiosemicarbazone) [Cu(II)KTS] with several compounds that cause inhibition of the synthesis of DNA by different biochemical mechanisms was assessed in Sarcoma 180 ascites cells. Cu(II)KTS prolonged the survival time of tumor-bearing mice, whereas neither cupric chloride, copper stearate, nor kethoxal bis(thiosemicarbazone) caused a significant lengthening of the life-span of similar animals. Synergistic… Expand
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