Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.

@article{Sun2007InhibitionOT,
  title={Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.},
  author={Jingjing Sun and M Zhu and S-W Wang and Shan Miao and Yan Xie and J-b Wang},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2007},
  volume={14 5},
  pages={353-9}
}
In Europe, swainsonine has been studied widely for prevention of metastasis and cancer therapy. In order to investigate the effects and mechanisms of swainsonine on the human gastric carcinoma SGC-7901 cell, we carried out in vivo and in vitro experiments. After treatment with swainsonine, an effective dose and IC50 value of swainsonine for SGC-7901 cells were examined by MTT assay. Cell-cycle distribution and apoptotic rates were analyzed using FCM, and [Ca2+]i was measured using LSCM. The… CONTINUE READING

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