Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

@inproceedings{Chae2017InhibitionOT,
  title={Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application},
  author={Young Kwang Chae and Keerthi Ranganath and Peter S. Hammerman and Christos Vaklavas and Nisha A Mohindra and Aparna Kalyan and Maria Matsangou and Ricardo L B Costa and Benedito A. Carneiro and Victoria Villaflor and Massimo Cristofanilli and Francis J Giles},
  booktitle={Oncotarget},
  year={2017}
}
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase signaling pathway that has a fundamental role in many biologic processes including embryonic development, tissue regeneration, and angiogenesis. Increasing evidence indicates that this pathway plays a critical role in oncogenesis via gene amplification, activating mutations, or translocation in tumors of various histologies. With multiplex sequencing technology, the detection of FGFR aberrations has… CONTINUE READING
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