Inhibition of the expression of hepatitis A and B viruses (HAV and HBV) proteins by interferon in a human hepatocarcinoma cell line (PLC/PRF/5).

@article{Berthillon1996InhibitionOT,
  title={Inhibition of the expression of hepatitis A and B viruses (HAV and HBV) proteins by interferon in a human hepatocarcinoma cell line (PLC/PRF/5).},
  author={Pascale Berthillon and Jean Marc Crance and François L{\'e}v{\^e}que and Alain Jouan and Marie Anne Petit and R. Deloince and Christian Tr{\'e}po},
  journal={Journal of hepatology},
  year={1996},
  volume={25 1},
  pages={15-9}
}
AIMS/METHODS PLC/PRF/5 is a continuous human hepatocarcinoma cell line whose genome contains integrated HBV DNA and which secretes two of the hepatitis B virus envelope proteins (HBs and PreS2). This line is also susceptible to infection by hepatitis A virus and was therefore used to compare the effects of interferon on protein synthesis of these two viruses and to assess the interactions which occur between them during infection. RESULTS Results showed that recombinant interferon alpha 2-a… CONTINUE READING