Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D.

@article{Nambiar1998InhibitionOT,
  title={Inhibition of the cytotoxicity of protein toxins by a novel plant metabolite, mansonone-D.},
  author={Madhusoodana P. Nambiar and Ramachandran Murugesan and H. C. Wu},
  journal={Journal of cellular physiology},
  year={1998},
  volume={176 1},
  pages={40-9}
}
We have studied the effect of several structurally related mansonones on the cytotoxicity of plant and bacterial toxins in Vero and BER-40, a brefeldin A-resistant mutant of Vero cells. Mansonone-D (MD), a sesquiterpenoid ortho-naphthoquinone, inhibited the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in Vero cells to different… CONTINUE READING