Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene.

@article{Niculescu1995InhibitionOT,
  title={Inhibition of the conversion of pre-interleukins-1 alpha and 1 beta to mature cytokines by p-benzoquinone, a metabolite of benzene.},
  author={Rodica Mariana Niculescu and Harlan N. Bradford and Rober t W. Colman and George F. Kalf},
  journal={Chemico-biological interactions},
  year={1995},
  volume={98 3},
  pages={
          211-22
        }
}
Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hematopoietic regulation through the synthesis of several cytokines including interleukin-1, which is required for production by stromal fibroblasts of a number of cytokines required… CONTINUE READING